by James Lyons-Weiler, PhD, Popular Rationalism, ©2023
(Oct. 28, 2023) — Having recently come through a nasty, prolonged non-COVID respiratory illness that came with days and days of severe cognitive decline, I did today what I always do: I checked out what research was available on the issue: Non-COVID-19-related brain fog.
Here’s an article I wrote when I “came back” from barely being able to hold a conversation.
In short, share this article with your doctors, and ask them if they know whether he flavonoid luteolin, the antioxidant N-acetylcysteine (NAC), magnesium L-threonate, and the central alpha agonist guanfacine can all act to help reduce brain fog so when it sets in, they feel comfortable helping you out. This is not medical advice. Talk with your physician, please!
Dr. Peter McCullough of course has published an empiric long-COVID protocol (3-12 months or more guided by clinical parameters (Nattokinase 2000 FU (100) mg orally twice a day without food, Bromelain 500 mg orally once a day without food, Curcumin 500 mg orally twice a day (nano, liposomal, or with piperine additive suggested – see their publication.) They did not specifically address brain fog.
Clearing the Fog Around Brain Fog
Many of us never heard of brain fog until the COVID-19 pandemic. Now, estimates of rates of brain fog are as high as 30% among adults. Brain fog is a term used to describe a constellation of symptoms that include reduced cognition, inability to concentrate, and loss of short and long-term memory. It’s not just a condition that affects those recovering from viral infections; it’s a widespread issue that can be triggered by various environmental factors such as air pollution, pesticides, and even certain foods.
Recent studies have shown that brain fog may be due to inflammatory molecules, including adipocytokines and histamine released from mast cells, which further stimulate microglia activation, causing focal brain inflammation(2). The good news is that there are many things people can do to reduce brain fog via choices they make in their daily lives.
What is Brain Fog?
A recent study (2) of first-person online descriptions of brain fog included forgetfulness (26%), difficulty concentrating (22%), dissociative phenomena (17%), cognitive ‘slowness’ and excessive effort (13%), communication difficulties (11%), ‘fuzziness’ or pressure (5%) and fatigue (4%).
Understanding the Environmental Causes
The Role of Inflammation
Inflammation is a natural response of the body to injury or infection. However, chronic inflammation can lead to various health issues, including brain fog. Inflammatory molecules like adipocytokines and histamine are released from mast cells and can stimulate microglia activation, causing localized brain inflammation (1).
Air Pollution
Air pollution is a significant environmental factor contributing to brain fog. Fine particulate matter (PM2.5) and volatile organic compounds (VOCs) can cross the blood-brain barrier, leading to oxidative stress and inflammation in the brain.
Pesticides
Exposure to certain pesticides like organophosphates has been linked to cognitive impairments. These chemicals can disrupt neurotransmitter activity, leading to symptoms of brain fog.
Food Additives
Artificial sweeteners, MSG, and other food additives can also contribute to brain fog. These substances can cause an imbalance in gut flora, leading to inflammation and, consequently, brain fog.
COVID-19 Infection, Vaccination
Studying three variants >12 days after infection, Diexer et al., found that fatigue and cognitive impairment were the most frequent symptoms.
Notably, in that study, the unvaccinated infected with the Omicron variant had the lowest risk of post-Covid-19 lingering symptoms.
Courageous Discourse™ with Dr. Peter McCullough & John Leake
Unvaccinated with Omicron Infection have Lowest Risk of Post-COVID Syndrome
Navigating Through the Fog: Treatment and Prevention
Understanding the environmental causes of brain fog is the first step in finding effective treatments. Lifestyle changes, such as avoiding exposure to pollutants and harmful chemicals, can make a significant difference.
Lifestyle Changes
One of the most effective ways to combat brain fog is through lifestyle changes. Simple adjustments like improving sleep quality, staying hydrated, and incorporating exercise into your daily routine can go a long way in enhancing cognitive function.
Nutritional Interventions
Diet plays a crucial role in cognitive health. Foods rich in antioxidants, Omega-3 fatty acids, and vitamins like B12 can help alleviate symptoms of brain fog. Moreover, avoiding foods that trigger inflammation, such as processed foods and sugary beverages, can be beneficial.
Natural Remedies
Natural remedies like herbal teas and supplements can also be effective. For instance, luteolin, a flavonoid found in herbs like thyme and parsley, has anti-inflammatory properties that can help treat brain fog(1).
Pharmacological Treatments
While lifestyle changes are the cornerstone of treating brain fog, some may require pharmacological interventions. Medications like nootropics and certain antidepressants have shown promise in improving cognitive function. However, it’s essential to consult a healthcare provider for a personalized treatment plan.
Environmental Adjustments
Reducing exposure to environmental triggers like air pollution and pesticides is crucial. Using air purifiers, avoiding the use of harmful chemicals in gardening and cleaning, and opting for organic produce can help mitigate the effects of these environmental factors.
Cognitive Behavioral Therapy (CBT)
For some, brain fog may have a psychological component. Cognitive Behavioral Therapy can help individuals understand the triggers and thought patterns that contribute to their symptoms.
The Flavone Luteolin
Interestingly, natural flavonoids like luteolin have shown promise in treating brain fog. Luteolin has antioxidant, anti-inflammatory, and neuroprotective properties(3).
Treatment and prevention of brain fog are multi-faceted. A combination of lifestyle changes, nutritional interventions, and, in some cases, pharmacological treatments can be effective in improving cognitive function.
Read the rest here.